Sex-biased expression of the TLR7 gene in severe COVID-19 patients: Insights from transcriptomics and epigenomicsArticle Published on 2022-12-012022-11-16 Journal: Environmental research [Category] 유전자 메커니즘, [키워드] acute phase analyzed Blood Cohort coronavirus disease COVID-19 COVID-19 patient CpG DNA DNA methylation dose downregulated embryogenesis epidemiological data epigenomic epigenomics Evidence expression female females gene product Genetic variation Genome-wide association studies Host inactivation incidence incidence of COVID-19 independent insight long-COVID-19 male males Methylation n-Counter. nasal patients Post-infection RNAseq Saliva Severe case severe COVID-19 severity Sex significantly higher stratified suggested timepoint TLR7 TLR7 gene transcriptomics with COVID-19 [DOI] 10.1016/j.envres.2022.114288 PMC 바로가기
COVID-19 and inflammatory bowel disease crosstalk: From emerging association to clinical proposalArticle Published on 2022-12-012022-11-16 Journal: Journal of medical virology [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] abdominal pain ACE2 acute respiratory syndrome addition association Autoimmune bowel Care caused coronavirus coronavirus disease COVID-19 COVID-19 epidemic diarrhea disease downregulated enzyme Epidemic etiology exacerbate expressed feasibility Genetic IBD IL-17 Imbalance immune activation immunosuppressive drug increase induce Infection Inflammatory Inflammatory bowel disease inflammatory bowel disease. inflammatory disease Inflammatory response intestinal intestinal inflammation intestine lung mechanism nonspecific overlapping pathway Patient patients Pneumonia progression protective factor receptor Research respiratory inflammation risk risk of COVID-19 SARS-CoV-2 SARS-COV-2 infection Symptom systemic symptom the cytokine storm the SARS-CoV-2 Treatment upregulated vaccination [DOI] 10.1002/jmv.28067 PMC 바로가기
Transcriptional regulation and small compound targeting of ACE2 in lung epithelial cellsArticle Published on 2022-11-012022-11-15 Journal: Acta pharmacologica Sinica [Category] COVID19(2023년), SARS, 진단, [키워드] 16HBE 16HBE cell 16HBE cells 6-O-angeloylplenolin ACE2 ACE2 expression addition administration Cell Centipeda Centipeda minima chemokine Chinese Compound conducted COVID-19 CX3CL1 CXCL13 dataset demonstrated downregulated entry of SARS-CoV-2 enzyme evaluated expression gene encoding HLF IL-6 inhibited inhibitor Interaction lung epithelial cell Lung epithelial cells lung tissue lung tissues mice modulate parental pathogen phosphorylated positively correlated promoter PROTECT Protein pseudovirus receptor reduced regulate Regulation S protein SARS-CoV-2 SARS-COV-2 infection screened STAT3 STAT3. stimulated suppressed target cells tested TFS Transcription transcription factor transfected with [DOI] 10.1038/s41401-022-00906-6 PMC 바로가기
Highly perturbed genes and hub genes associated with type 2 diabetes in different tissues of adult humans: a bioinformatics analytic workflowArticle Published on 2022-10-012022-11-16 Journal: Functional & integrative genomics [Category] meta-analysis, [키워드] analysis Apoptosis applied approach association bioinformatics cell type complex defined diabete diabetes Differential gene expression differentially expressed gene downregulated downstream analysis eligible etiology FIVE Gene Expression Gene Expression Omnibus Genes Genetic greater Highly perturbed genes hub gene hub genes identify insulin Kyoto Manifestations marker gene Meta-analysis metabolomics Microarray non-specific ontologies Pathogenesis pathophysiological pathway Pathways Perturbation profiles provided random effect significantly systematic review T2D tissue Type type 2 diabete type 2 diabetes. upregulated utility [DOI] 10.1007/s10142-022-00881-5 PMC 바로가기
Evaluation of the immunomodulatory effects of interleukin-10 on peripheral blood immune cells of COVID-19 patients: Implication for COVID-19 therapyArticle Published on 2022-09-062022-11-15 Journal: Frontiers in Immunology [Category] SARS, 진단, [키워드] addition Analysis Antigen CD8 Cell Cohort Control controls COVID-19 COVID-19 patient cytokine downregulated Effect elevated ELISA enrolled evaluated expression FGF Flow cytometry analysis Frequency function GM-CSF highest HLA-DR Hospitalized IFN-γ IL-10 IL-2 IL-6 immune Immune cell immune factor immune factors immunomodulatory effect in vivo Infection Inflammation information investigated MCP-1 modulating multiplex Multiplex assay Natutal Killer Cells NK cells not affect Peripheral blood plasma platform producing provide reached reduce remained SARS-CoV-2 significantly spike stimulated subject survival T cell T-cell therapy TNF-α treated was collected were measured whole-blood. with COVID-19 [DOI] 10.3389/fimmu.2022.984098 PMC 바로가기
Presepsin Predicts Severity and Secondary Bacterial Infection in COVID-19 by Bioinformatics AnalysisArticle Published on 2022-09-062022-11-15 Journal: Computational and Mathematical Methods in Medicine [Category] SARS, 바이오마커, [키워드] acute respiratory disease Analysis AUC biological processes caused CD14 cellular components Coronavirus pneumonia COVID-19 COVID-19 patient Critical datasets deaths DEGs Diagnosis diagnostic value differentially expressed gene downregulated enrichment analysis expression function Gene ontology KEGG Kyoto limit majority moderate molecular function nonsurvivor novel novel coronavirus SARS-CoV-2 Pathway enrichment analysis PPI predict Prognosis protein-protein interaction screened secondary secondary bacterial infection selected severe COVID-19 severe COVID-19 patient severity significantly significantly higher significantly increased survivor Treatment upregulated utility was performed [DOI] 10.1155/2022/9914927 PMC 바로가기
Lung epithelial and myeloid innate immunity in influenza-associated or COVID-19-associated pulmonary aspergillosis: an observational studyResearch article Published on 2022-08-242022-10-05 Journal: The Lancet. Respiratory Medicine [Category] COVID19(2023년), SARS, 바이오마커, 유전자 메커니즘, 진단, [키워드] admitted to ICU Affect affecting Analysis Antwerp Aspergillus autophagy Belgium Bronchoalveolar lavage fluid bronchoalveolar lavage sample bronchoalveolar lavage samples calculate Cell chemokines collected Concentration conidia COVID-19 Critically ill patient Cytokines development diagnose differentially expressed disrupting downregulated downregulation elevated Eligible patients encoding protein enrichment analysis epithelial European expression expression data finding foundation fraction France function funding Gene expression analysis growth factor Horizon hospital hyphae ICU IFNγ IL-1β Immunity in vivo increased mortality Influenza Influenza virus Innate immunity intensive care invasive invasive ventilation investigated kill killing lung epithelial Max Planck Society network neutrophil Neutrophils Non-invasive pathophysiology pathway Pathway analysis Pathways Patient patients patients with COVID-19 patients with influenza performed phagocytosis Protein recruited Regional retrieved SARS-COV-2 infection SARS-CoV-2 RNA several gene significantly significantly lower spores TNF-α tracheobronchial transcriptomics Treatment Type I IFN type II IFN university University Hospitals Leuven were used [DOI] 10.1016/S2213-2600(22)00259-4 [Article Type] Research article
Gene Network Analysis of the Transcriptome Impact of SARS-CoV-2 Interacting MicroRNAs in COVID-19 DiseaseCOVID-19 질병에서 SARS-CoV-2 상호작용 MicroRNA의 전사체 영향에 대한 유전자 네트워크 분석Review Published on 2022-08-172022-09-11 Journal: International Journal of Molecular Sciences [Category] SARS, 유전자 메커니즘, [키워드] affected Analysis biochemical biological processes Cell cell cycle cell surface receptor changes characterized COVID-19 COVID-19 disease cytokine death DEGs differentially expressed differentially expressed gene Differentially expressed genes downregulated exploratory FIVE functional enrichment Functional enrichment analysis Gene Expression gene network Health Organization heart Impact involved kidneys list lung Lymph node microRNA MicroRNAs mitochondrial mitotic mitotic cell modulation molecular Multiorgan multiorgan disease network network analysis network analysis. pathological mechanism Pathways Perspective predicted provide reported SARS-CoV-2 SARS-CoV-2 virus signaling pathway submitted surface receptor target tissue tissues transcriptomes translated upregulated WHO with COVID-19 World Health Organization [DOI] 10.3390/ijms23169239 PMC 바로가기 [Article Type] Review
Four cases of cytokine storm after COVID-19 vaccination: Case reportArticle Published on 2022-08-152022-11-15 Journal: Frontiers in Immunology [Category] 유전자 메커니즘, 진단, [키워드] adverse event Autopsy Blood Care control group controls coronavirus disease COVID-19 COVID-19 vaccine cytokine signaling Cytokine storm death died differentially expressed disease downregulated drugs Fever immune dysregulation immunology International involved mechanism neutrophil degranulation observation occur occurred pandemic RNA RNA sequencing second dose Side effects upregulated vaccination vaccination. Vaccine [DOI] 10.3389/fimmu.2022.967226 PMC 바로가기
Combining Deep Phenotyping of Serum Proteomics and Clinical Data via Machine Learning for COVID-19 Biomarker DiscoveryCOVID-19 바이오마커 발견을 위한 기계 학습을 통한 혈청 단백질체학 및 임상 데이터의 심층 표현형 결합Article Published on 2022-08-152022-09-11 Journal: International Journal of Molecular Sciences [Category] 바이오마커, 유전자 메커니즘, [키워드] analyzed Biomarker Biomarkers cardiometabolic CD200R1 Central nervous system clinical Clinical practice contributed COVID-19 COVID-19 disease COVID-19 disease severity COVID-19 patient dataset deep disease disease severity Diseases downregulated enrolled Factors IL6 IMPROVE Inflammation KIT LTBP2 lymphocyte lymphocyte counts machine learning MATN3 MCP1 MOST MRAP natural history neurologic neurologic disease neutrophil nine outcome pathology persistence Phenotyping Protective Protein proximity extension assay proximity extension assay. sera serological data serum biomarker serum biomarkers severe cases small sample size statistical TRANCE unique variable [DOI] 10.3390/ijms23169161 PMC 바로가기 [Article Type] Article